Table 1.
Organism, MIC, and outcome
| Organism | N | Vori cona zole |
Natamycin | Voriconazole | 3 week BSCVA (95% CI)** |
3 month BSCVA (95% CI)** |
3 week infiltrate/ scar size (95% CI)** |
3 month infiltrate/ scar size (95% CI)** |
Perforation (%) |
Time to re- epithelialization, median, days (95% CI) |
||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC50 (μg/ml) |
MIC90 * (μg/ml) |
MIC50 (μg/ml) |
MIC90 * (μg/ml) |
|||||||||
|
Aspergillus
spp 1 |
17 | 7 | 32 | 32 | 1 | 1 | 0.80 (0.45, 1.15) |
0.68 (0.29, 1.06) |
4.50 (3.66, 5.33) |
4.57 (3.67, 5.47) |
4 (25%) | 20.5 (11.5, NE***) |
| A. flavus | 11 | 6 | 32 | 32 | 1 | 1 | 0.85 (0.43, 1.26) |
0.77 (0.31, 1.24) |
4.62 (3.52, 5.71) |
4.79 (3.62, 5.96) |
2 (18%) | 15 (4, NE) |
| A. fumigatus | 5 | 0 | 4 | 8 | 0.5 | 0.5 | 0.85 (0.43, 1.26) |
0.57 (−0.10, 1.24) |
4.65 (3.55, 5.74) |
4.55 (3.43, 5.67) |
2 (40%) | 20.5 (20.5, NE) |
| Fusarium spp | 44 | 23 | 4 | 8 | 4 | 16 | 0.66 (0.42, 0.89) |
0.40 (0.19, 0.61) |
4.20 (3.64, 4.75) |
4.00 (3.44, 4.57) |
7 (16%) | 14 (5, NE) |
| Bipolaris | 6 | 4 | 4 | 4 | 0.5 | 8 | 0.28 (0.07, 0.48) |
0.25 (0.09, 0.41) |
2.99 (1.74, 4.24) |
2.96 (1.93, 3.99) |
2 (33%) | 11.5 (4, NE) |
| Curvularia | 8 | 4 | 4 | 256 | 0.5 | 2 | 0.64 (0.20, 1.08) |
0.58 (0.03, 1.13) |
3.34 (2.74, 4.19) |
3.07 (2.42, 3.73) |
0 (0%) | 13.5 (4, NE) |
| Exserohilum | 4 | 0 | 4 | 4 | 1 | 2 | 0.66 (0.43, 0.90) |
0.51 (−0.47, 1.49) |
3.88 (2.31, 5.44) |
3.77 (1.57, 5.97) |
0 (0%) | 5 (4.5, NE) |
| Lasiodiplodia | 3 | 3 | 4 | 32 | 2 | 4 | 0.68 (−0.14, 1.51) |
0.70 (−0.13, 1.53) |
4.69 (3.62, 5.75) |
4.71 (3.58, 5.83) |
0 (0%) | 7 (7, NE) |
| Scedosporium | 2 | 1 | 8 | 8 | 0.5 | 0.5 | 0.10 **** |
0.0 | 2.86 | 2.86 | 0 (0%) | NE |
| P | 0.21 | <0.001 | <0.001 | 0.84 | 0.82 | 0.55 | 0.39 | 0.60 | 0.73 | |||
| Total | 84 | 42 | 4 | 32 | 2 | 8 | 0.65 (0.49, 0.81) |
0.48 (0.32, 0.63) |
4.07 (3.69, 4.45) |
3.96 (3.56, 4.35) |
13 (15%) | 15 (5, NE) |
1
There was one Aspergillus terreus organism isolated
*
Highest value for organisms with fewer than 9 observations
**
95% confidence intervals estimated by accelerated bootstrap, 1000 resamplings. Infiltrate-scar size is the geometric mean of the largest scar diameter and the largest perpendicular, in mm. BSCVA is logMAR.
***
NE: Not estimable
****
Only 1 observation at 3 weeks and 3 months, no 95% CI