Table 3.
Associations between HDL genetic risk scores and HDL, LDL, triglycerides, and coronary artery calcified plaque (CAC)
| |
Model 1 |
Model 2 |
Model 3 |
|||
|---|---|---|---|---|---|---|
| β Estimate (CI) | p-value | β Estimate (CI) | p-value | β Estimate (CI) | p-value | |
|
HDL |
|
|
|
|
|
|
| Risk score 1a |
0.027 (-0.001- 0.055) |
0.057 |
0.030 (0.005- 0.056) |
0.022 |
0.033 (0.007- 0.058) |
0.013 |
| Risk score 1b |
0.033 (0.003- 0.063) |
0.031 |
0.034 (0.006- 0.061) |
0.018 |
0.035 (0.008- 0.063) |
0.012 |
| Risk score 2a |
0.046 (0.016- 0.076) |
0.003 |
0.051 (0.023- 0.079) |
3.85 × 10-4 |
0.052 (0.024- 0.080) |
3.06 × 10-4 |
| Risk score 2b |
0.061 (0.034- 0.089) |
1.42 × 10-5 |
0.062 (0.036- 0.088) |
2.60 × 10-6 |
0.063 (0.037- 0.088) |
1.44 × 10-6 |
| Combined unweighted |
0.035 (0.015- 0.055) |
0.001 |
0.039 (0.021- 0.058) |
3.63 × 10-5 |
0.040 (0.021- 0.058) |
2.34 × 10-5 |
| Combined weighted |
0.043 (0.025- 0.061) |
4.65 × 10-6 |
0.044 (0.027- 0.061) |
4.90 × 10-7 |
0.044 (0.027- 0.061) |
2.75 × 10-7 |
|
LDL |
|
|
|
|
|
|
| Risk score 1a |
0.317 (-0.678- 1.311) |
0.532 |
0.260 (-0.74- 1.260) |
0.611 |
0.245 (-0.759- 1.248) |
0.633 |
| Risk score 1b |
0.243 (-0.782- 1.268) |
0.642 |
0.177 (-0.854- 1.207) |
0.737 |
0.140 (-0.887- 1.167) |
0.789 |
| Risk score 2a |
−0.823 (-1.978- 0.332) |
0.163 |
−0.838 (-1.987- 0.312) |
0.153 |
−0.805 (-1.955- 0.346) |
0.170 |
| Risk score 2b |
−0.507 (-1.614- 0.600) |
0.369 |
−0.604 (-1.713- 0.506) |
0.286 |
−0.585 (-1.698- 0.529) |
0.303 |
| Combined unweighted |
−0.243 (-1.018- 0.533) |
0.539 |
−0.261 (-1.033- 0.512) |
0.509 |
−0.266 (-1.038- 0.507) |
0.501 |
| Combined weighted |
−0.260 (-0.988- 0.468) |
0.484 |
−0.325 (-1.054- 0.404) |
0.383 |
−0.327 (-1.060- 0.406) |
0.381 |
|
Triglycerides |
|
|
|
|
|
|
| Risk score 1a |
−0.002 (-0.019- 0.015) |
0.853 |
−0.005 (-0.021- 0.012) |
0.591 |
−0.006 (-0.022- 0.010) |
0.469 |
| Risk score 1b |
−0.005 (-0.022- 0.013) |
0.595 |
−0.007 (-0.024- 0.010) |
0.402 |
−0.008 (-0.024- 0.009) |
0.374 |
| Risk score 2a |
−0.013 (-0.034- 0.008) |
0.220 |
−0.016 (-0.036- 0.004) |
0.123 |
−0.015 (-0.036- 0.005) |
0.133 |
| Risk score 2b |
−0.009 (-0.028- 0.010) |
0.370 |
−0.013 (-0.031- 0.005) |
0.162 |
−0.013 (-0.031- 0.005) |
0.163 |
| Combined unweighted |
−0.010 (-0.023- 0.004) |
0.157 |
−0.012 (-0.025- 0.001) |
0.076 |
−0.012 (-0.025- 0.001) |
0.072 |
| Combined weighted |
−0.007 (-0.020- 0.005) |
0.246 |
−0.010 (-0.022- 0.002) |
0.092 |
−0.010 (-0.022- 0.002) |
0.096 |
|
Coronary Artery Calcified Plaque (CAC) |
|
|
|
|
|
|
| Risk score 1a |
−0.079 (-0.154- -0.003) |
0.042 |
−0.065 (-0.128- -0.001) |
0.046 |
−0.068 (-0.128- -0.008) |
0.027 |
| Risk score 1b |
−0.067 (-0.146- 0.012) |
0.097 |
−0.053 (-0.119- 0.014) |
0.119 |
−0.059 (-0.123- 0.004) |
0.065 |
| Risk score 2a |
−0.072 (-0.154- 0.011) |
0.089 |
−0.063 (-0.134- 0.009) |
0.085 |
−0.082 (-0.149- -0.014) |
0.017 |
| Risk score 2b |
−0.117 (-0.197- -0.036) |
0.005 |
−0.088 (-0.156- -0.020) |
0.011 |
−0.101 (-0.163- -0.038) |
0.002 |
| Combined unweighted |
−0.083 (-0.140- -0.026) |
0.004 |
−0.077 (-0.123- -0.031) |
0.001 |
−0.080 (-0.124- -0.037) |
3.18 × 10-4 |
| Combined weighted | −0.087 (-0.141- -0.033) | 0.002 | −0.069 (-0.114- -0.024) | 0.002 | −0.075 (-0.117- -0.034) | 3.85 × 10-4 |
Analysis was performed using marginal models with generalized estimating equations. Model 1 is unadjusted; Model 2 is adjusted for age, sex, and body mass index (BMI); Model 3 is adjusted for age, sex, BMI, smoking, hypertension, and prior cardiovascular disease. Associations are reported as the β estimate and its 95% confidence interval (CI).