Table 2.

Potential therapeutic interventions and effects on targets of inflammatory network

Therapies	Target effects
Monoclonal antibodies against these cytokines and their receptors	Reduction of levels of IL-6, TNF-α
Non-steroidal anti-inflammatory drug
Agonists of cytokine receptors or PRR receptors for people who do not respond to (or comply with) NSAID therapy
Antibody-mediated stimulation of the decoy TLR receptors, such as TAM receptors, or of the intracellular TLR regulators for people with pro-inflammatory alleles in TLR4 and TLR2 genes
Statin therapy
Physical activity
Administration of prebiotics and probiotics
Caloric restriction	Decrease of oxidative stress
Polyphenols
Use of drugs having mimic CR action
Caloric restriction	Mitochondria biogenesis as preventive action against mitochondrial dysfunction
Use of drugs having mimic CR action
Polyphenols
Caloric restriction	Reduction of the activation of NF-KB pathway
Terpenoids
Resveratrol
Use of specific miRNAs
Administration of prebiotics and probiotics
Use of drugs having mimic CR action Curcumin
Caloric restriction: inhibition of mTOR pathway	Preventive action on the possible reduced activity of autophagic cleansing
Rapamycin: inhibition of mTOR pathway
Curcumin: influences the mTOR pathway
Caloric restriction	Reduction of the excessive activation of Insulin/IGF1 pathway
Metformin with CR mimic response