Figure 2. Neither acute nociception nor motor coordination is disrupted by pioglitazone.

After baseline assessment of noxious heat, noxious pressure, or latency to fall off of a rotating bar (rotarod), the highest dose of pioglitazone (10 mg/kg/d, i.p.) was administered for 7 days, followed by behavioral reassessment. Pioglitazone did not change behavioral withdrawal responses to noxious heat (A) or pressure (B), nor did it affect motor coordination (C). n=7 for vehicle and n=9 for pioglitazone.