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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Neuropharmacology. 2013 Feb 13;70:236–246. doi: 10.1016/j.neuropharm.2013.01.020

Figure 3. The anti-allodynic effects of chronic pioglitazone are long lasting.

Figure 3

Saline (Vehicle) or drug (Pio 10 mg/kg/d) administration (i.p.) was started 15 min prior to SNI surgery and continued twice daily for 7 days (yellow bars). Pioglitazone reduced hypersensitivity to vF (A), cold (B), and pin prick (C). These effects lasted well-beyond cessation of drug administration (n = 6 per group). Values represent mean ± SEM. (★) denotes significant difference (p<0.05 vs. vehicle by Bonferroni post-tests following repeated measures 2-way ANOVA).