Figure 5. Inhibition of uptake of nAbs-PrP and ft-PrP by specific blockers.

Western blot analysis of antibody uptake in microglial cells was performed following pre-treatment with cytochalasin D, fucoidan or wortmannin or the co-administration of fucoidan and wortmannin. Cells were co-incubated with PrP106-126 A117V and nAbs-PrP or ft-PrP (A) or with nAbs-PrP or ft-PrP alone (B). One representative experiment out of three is shown.