Main effects on vascular function of a switch from PI, EX (voluntary wheel running), or CAT (30 mg/kg/day in drinking water) with a RD from the age of 1 to 9 months to PI and a WD from the age of 9 to 12 months. Ach induced endothelium-dependent relaxation of the aorta (a, b, c; n=4–9) and femoral arteries (d, e, f; n=5–9) and flow-mediated endothelium-dependent dilation of cerebral arteries (g, h, i; n=6–10). Results are presented as the mean±SEM. *p<0.05 compared to 12 months of age with RD (treatment matching group), Pp<0.05 compared to PI, Ep<0.05 compared to EX, and Cp<0.05 compared to CAT