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. 2013 Jun 28;8(6):e67963. doi: 10.1371/journal.pone.0067963

Figure 2. Clinical and genetic characterization.

Figure 2

(A) Electropherogram of SCN5A mutation c.4477–4479delAAG and multiple sequence alignment of amino acids of human SCN5A protein regions bearing the identified in-frame deletion mutation of lysine (p.1492delK) with corresponding SCN5A amino acid sequences of different species. (B) Electrocardiogram of patient 10021_49 shows an atrioventricular block first-degree, an increased P-wave duration and an intraventricular conduction delay (P interval 145 ms, PQ interval 208 ms, QRS interval 146 ms). (C) Ajmaline challenge of patient 10021_149, overall 54 mg ajmaline (1mg/kg) was administered within 5 minutes. No Brugada type I ECG could be unmasked, but cardiac conduction delay aggravated.