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. 2013 Jun 28;8(6):e68362. doi: 10.1371/journal.pone.0068362

Figure 2. Phenotypic effects of aromatase overexpression in embryonic gonads.

Figure 2

The urogenital systems of control and RCASBP-Aromatase virus infected E10.5 embryos. (A) Wholemount brightfield imaging (4×magnification) shows the mesonephric kidneys (Ms), and the right gonad (Rg) and left gonad (Lg), which is delineated by the black dashed lines. Gonadal asymmetry by enlargement of the left gonad of the RCASBP-Aromatase infected male is evident. (B) Haematoxylin and eosin staining of the left gonads of control and RCASBP-Aromatase injected embryos. The cortex and medulla regions for each are indicated and arrows highlight selected germ cells. Control males have a minimal cortex and large medulla, and very few germ cells, whereas the control female, and the RCASBP-Aromatase infected female and male have a thickened outer cortex and large numbers of germ cells.