Figure 3. LXM-10 induced suppression of TNF-α and IL-6 was attenuated by methyllycaconitine citrate and tropicamide.

Rats were treated with methyllycaconitine citrate (MLA, 3 mg/kg, i.p.), tropicamide (Tro, 3 mg/kg, i.p.) or vehicle prior to administration of LXM-10 (6 mg/kg, i.g.) or vehicle, and the levels of TNF-α (A) and IL-6 (B) were measured in hind paws at 3 h after carrageenan challenge. All data are mean ± SEM of 6∼8 rats per group. ^** P<0.01 vs Vehicle and ^# P<0.05 vs LXM-10 at the same time point.