Figure 4. Effect of LXM-10 on expression of P-JAK2 was attenuated by methyllycaconitine citrate and tropicamide.

The rats were treated with methyllycaconitine citrate (MLA, 3 mg/kg, i.p.), tropicamide (Tro, 3 mg/kg, i.p.) or vehicle before administration of LXM-10 (6 mg/kg, i.g.) or vehicle. The expression of JAK2 and P-JAK2 in hind paws was detected at 3 h after carrageenan challenge. All data are mean ± SEM of 6 rats per group. ^** P<0.01 vs Vehicle; ^# P<0.05 and ^## P<0.01 vs LXM-10.