Table 4. Predictors of major first-line modification by income grouping.
AHOD | TAHOD-High | TAHOD-Low | ||||
Hazard Ratio | p | Hazard Ratio | p | Hazard Ratio | p | |
Sex | ||||||
Male | 1.00 | 1.00 | 1.00 | |||
Female | 0.92 (0.55–1.55) | 0.75 | 0.93 (0.7–1.25) | 0.64 | 0.76 (0.56–1.03) | 0.08 |
Age at ART initiation (years) | ||||||
<30 | 1.00 | 1.00 | 1.00 | |||
30–50 | 1.07 (0.76–1.49) | 0.71 | 0.79 (0.61–1.03) | 0.08 | 1.04 (0.77–1.4) | 0.81 |
>50 | 1.14 (0.76–1.71) | 0.52 | 0.87 (0.6–1.25) | 0.45 | 0.81 (0.46–1.44) | 0.47 |
Exposure | ||||||
Homosexual | 1.00 | 1.00 | 1.00 | |||
Heterosexual | 0.92 (0.63–1.34) | 0.67 | 1.34 (0.97–1.86) | 0.08 | 1.17 (0.69–1.98) | 0.56 |
IDU | 1.29 (0.81–2.07) | 0.28 | 1.57 (0.81–3.05) | 0.18 | 1.16 (0.58–2.33) | 0.67 |
Other | 0.93 (0.67–1.27) | 0.63 | 1.08 (0.66–1.75) | 0.77 | 0.98 (0.52–1.86) | 0.96 |
Hepatitis B | ||||||
Neg/Not Tested | 1.00 | 1.00 | 1.00 | |||
Positive | 1.05 (0.59–1.84) | 0.88 | 1.21 (0.88–1.66) | 0.24 | 1.14 (0.68–1.9) | 0.62 |
Hepatitis C | ||||||
Neg/Not Tested | 1.00 | 1.00 | 1.00 | |||
Positive | 0.63 (0.4–0.97) | 0.04 | 0.87 (0.53–1.41) | 0.56 | 0.65 (0.39–1.11) | 0.12 |
Year of ART Initiation | ||||||
1996–2004 | 1.00 | 1.00 | 1.00 | |||
2005–2011 | 0.81 (0.64–1.02) | 0.08 | 0.7 (0.54–0.91) | 0.01 | 0.62 (0.48–0.81) | <0.001 |
No | 1.00 | 1.00 | 1.00 | |||
Yes | 1.43 (1.02–2.01) | 0.04 | 0.97 (0.77–1.21) | 0.77 | 1.15 (0.88–1.5) | 0.32 |
CD4 cell count at ART initiation (cells/µL) * | ||||||
0–199 | 1.00 | 1.00 | 1.00 | |||
200–350 | 1 (0.75–1.35) | 0.99 | 1.28 (0.92–1.76) | 0.14 | 1.19 (0.86–1.64) | 0.29 |
350–500 | 1.1 (0.78–1.55) | 0.60 | 1.45 (0.93–2.25) | 0.10 | 0.61 (0.19–1.93) | 0.40 |
>500 | 0.99 (0.68–1.45) | 0.97 | 1.86 (1–3.45) | 0.05 | 1.77 (0.72–4.36) | 0.21 |
Unknown | 1.12 (0.63–2.01) | 0.69 | 1.1 (0.79–1.54) | 0.58 | 1.24 (0.83–1.85) | 0.29 |
RNA–VL at ART initiation (copies/ml) * | ||||||
1–104 | 1.00 | 1.00 | 1.00 | |||
104–106 | 0.76 (0.52–1.11) | 0.15 | 0.71 (0.44–1.17) | 0.18 | 1.59 (0.54–4.72) | 0.40 |
>106 | 0.81 (0.55–1.17) | 0.26 | 0.78 (0.49–1.25) | 0.31 | 2.24 (0.8–6.27) | 0.13 |
Unknown | 0.79 (0.43–1.44) | 0.44 | 1.01 (0.62–1.64) | 0.96 | 1.46 (0.54–3.99) | 0.46 |
Hazard ratios calculated from multivariable model including adjustment for site resourcing.
Closest record to ART initiation within a window of 6 month prior to ART and 1 week following ART initiation.