Table 2. Univariate and multivariate analysis of predictors on postoperative early relapse for 107 UICC1 stage II-III colorectal cancer patients undergoing curative resection.
| Non-early relapse | Early relapse | Univariate analysis | Multivariate analysis | ||
| Parameters | (N = 56) (%) | (N = 51) (%) | P value | OR2 (95% CI3) | P value |
| Gender (Female/Male) | 20/36 | 21/30 | 0.562 | 1.051(0.421–2.661 ) | 0.916 |
| Age (<65/≧65)(y/o) | 18/38 | 23/28 | 0.168 | 0.791(0.310–2.035 ) | 0.624 |
| Size (<5/≧5)(cm) | 32/24 | 24/27 | 0.297 | 1.397(0.536–3.702 ) | 0.494 |
| Depth (/T2/T3+T4) | 3/53 | 1/50 | 0.343 | 5.074(0.515–118.151) | 0.170 |
| Stage (II/III) | 34/22 | 23/28 | 0.105 | 1.652(0.626–4.457) | 0.311 |
| Vascular invasion (No/Yes) | 44/12 | 32/19 | 0.071 | 0.778(0.235–2.444 ) | 0.669 |
| Perineural invasion (No/Yes) | 48/8 | 31/20 | 0.003 | 4.516(1.442 –15.424) | 0.009 |
| Grade (PD/WD+MD4) | 6/50 | 8/43 | 0.446 | 5.346(0.707 –63.816) | 0.109 |
| Type (M+S/Ac5) | 2/54 | 9/42 | 0.014 | 0.053(0.003–0.504) | 0.008 |
| miRNA-29c expression6Mean±SD7 | 0.67±0.71 | 0.37±0.59 | 0.021 | 2.722 (1.301–6.172) | 0.007 |
1
UICC: Union for International Cancer Control;
2
OR: Odds ratio;
3
CI: Confidence interval.
4
WD:Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated.
5
Ac: Adneocarcinoma; M: Mucinous carcinoma; S: Signet-ring cell carcinoma.
6
The relative expression level of miRNA-29c is represented by log10 (2−ΔCt). ΔCt = (CtmiRNA-29c - CtU6b), with U6b as the internal control for normalization.
7
SD: Standard deviation.