Table 3. Univariable association of donor, recipient, surgical, allo-sensitization, and immunosuppressive agents with risk of technical failure.
The univariable unadjusted association hazard ratio (HR), confidence interval [lower confidence level (LCL) and upper confidence level (UCL)], and p values.
| Hazard Ratio | LCL | UCL | p value | |
|---|---|---|---|---|
| Transplant Type | ||||
| PTA | 0.96 | 0.64 | 1.45 | 0.855 |
| PAK | 0.71 | 0.48 | 1.04 | 0.078 |
| SPK | 1.52 | 1.04 | 2.23 | 0.031 |
| Recipient Characteristics | ||||
| Female | 0.78 | 0.54 | 1.13 | 0.196 |
| Age | 0.95 | 0.77 | 1.17 | 0.621 |
| BMI | ||||
| <25 | - | - | - | 0.232 |
| 25–30 | 1.27 | 0.83 | 1.93 | 0.269 |
| >30 | 1.54 | 0.92 | 2.57 | 0.103 |
| Retransplant | 1.06 | 0.69 | 1.63 | 0.781 |
| Pretransplant Vascular Disease | 0.86 | 0.59 | 1.26 | 0.440 |
| Pretransplant Dialysis | 0.99 | 0.68 | 1.44 | 0.974 |
| Smoker | 0.75 | 0.51 | 1.09 | 0.135 |
| Donor Characteristics | ||||
| Female | 0.89 | 0.61 | 1.31 | 0.558 |
| Age | 1.03 | 1.01 | 1.04 | < 0.001 |
| Age 50 or Older | 2.08 | 1.19 | 3.64 | 0.010 |
| Race: White | 0.86 | 0.42 | 1.77 | 0.687 |
| Race: African American | 1.07 | 0.47 | 2.44 | 0.866 |
| Race: Asian | 0.97 | 0.14 | 6.93 | 0.974 |
| Body Mass Index | 1.08 | 1.04 | 1.12 | < 0.001 |
| BMI >30 | 1.75 | 1.16 | 2.63 | 0.007 |
| Cause of Death - Stroke | 1.45 | 1.00 | 2.12 | 0.052 |
| Cause of Death - Head Trauma | 0.69 | 0.48 | 1.00 | 0.049 |
| Social History - Alcohol Abuse | 1.69 | 0.98 | 2.92 | 0.058 |
| Social History - Drug Abuse | 0.86 | 0.35 | 2.12 | 0.742 |
| Past Medical History - Pancreatitis | 7.39 | 2.34 | 23.29 | < 0.001 |
| Donation After Cardiac Death | 0.30 | 0.04 | 2.15 | 0.231 |
| Elevated Creatinine | 3.06 | 1.49 | 6.30 | 0.002 |
| Elevated Amylase | 1.62 | 0.79 | 3.33 | 0.191 |
| Preservation Time (Hours) | 1.06 | 1.02 | 1.10 | 0.004 |
| Preservation Time 20 Hours or Greater | 1.82 | 1.25 | 2.65 | 0.002 |
| Interval Admit to Brain Death (Days) | 0.89 | 0.69 | 1.16 | 0.386 |
| Pancreas Donor Risk Index (pDRI) | 1.89 | 1.48 | 2.40 | < 0.001 |
| Surgical Factors | ||||
| Bladder Drainage | 0.69 | 0.48 | 1.00 | 0.052 |
| Allosensitization | ||||
| Peak PRA Class I | 1.00 | 1.00 | 1.01 | 0.544 |
| Peak PRA Class II | 1.00 | 0.99 | 1.01 | 0.946 |
| Peak PRA Overall | 1.00 | 0.99 | 1.01 | 0.691 |
| Zero Mismatches | 1.24 | 0.60 | 2.54 | 0.560 |
| Peak PRA Greater than 80% | 0.89 | 0.50 | 1.58 | 0.679 |
| Immunosuppression | ||||
| Thymoglobulin or Atgam | 0.87 | 0.49 | 1.56 | 0.645 |
| Campath | 0.63 | 0.36 | 1.08 | 0.093 |
| IL-2R Monoclonal Antibody | 1.03 | 0.71 | 1.49 | 0.884 |
| Tacrolimus | 0.87 | 0.54 | 1.42 | 0.582 |
| Cyclosporine | 0.94 | 0.35 | 2.56 | 0.909 |
| MMF | 1.01 | 0.53 | 1.94 | 0.968 |
| Prednisone | 0.79 | 0.55 | 1.15 | 0.223 |