Fig. 2.
Effect of SRIF on delayed outward K+ current (IK) in rods. A, SRIF increased voltage-activated K+ current. IK was evoked by holding cells at −70 mV and applying depolarizing steps from −60 to +40 mV in 20 mV increments in control external solution (left) and after a 4 min exposure to 0.5 μm SRIF (stripedhorizontalbar; right). B,I–V relationship of IKobtained from the experiment described in A is shown. Inset, Somatostatin increasedIK amplitude without substantially changing the current–voltage relation. ■, Control; ○, somatostatin. They-axis of the inset is normalized current. C, CTX reduced outward currents (left) but did not prevent a somatostatin-induced increase in IK. D, I–Vrelationship of outward current in the presence of CTX (■), or CTX + somatostatin (▵); n = 3.