Table 3. Frequencies of alleles and genotypes of IL23R polymorphisms in AS patients and controls.
SNP | Genotype | AS | Controls | χ2 | P | pc | OR |
Allele | (N = 291) | (N = 312) | value | (95% CI) | |||
rs17375018 | AA | 18(6.2%) | 26(8.3%) | 1.027 | 0.311 | NS | 0.73(0.39–1.35) |
AG | 108(37.1%) | 136(43.6%) | 2.621 | 0.105 | NS | 0.76(0.55–1.06) | |
GG | 165(56.7%) | 150(48.1%) | 4. 488 | 0.034 | NS | 1.41(1.03–1.95) | |
A | 144(24.7%) | 188(30.1%) | 4.379 | 0.036 | NS | 0.76(0.59–0.98) | |
G | 438(75.3%) | 436(69.9%) | 4.379 | 0.036 | NS | 1.31(1.02–1.69) | |
rs7517847 | TT | 104(35.7%) | 98(31.4%) | 1.266 | 0.260 | NS | 1.21(0.87–1.70) |
GT | 146(50.2%) | 153(49.0%) | 0.077 | 0.781 | NS | 1.05(0.76–1.44) | |
GG | 41(14.1%) | 61(19.6%) | 3.196 | 0.074 | NS | 0.68(0.44–1.04) | |
G | 228(39.2%) | 275(44.1%) | 2.968 | 0.085 | NS | 0.82(0.65–1.03) | |
T | 354(60.8%) | 349(55.9%) | 2.968 | 0.085 | NS | 1.22 (0.97–1.54) | |
rs11209032 | GG | 53(18.2%) | 59(18.9%) | 0.048 | 0.826 | NS | 0.96(0.63–1.44) |
AG | 150(51.5%) | 167(53.5%) | 0.237 | 0.627 | NS | 0.92(0.67–1.27) | |
AA | 88(30.3%) | 86(27.6%) | 0.525 | 0.469 | NS | 1.14(0.80–1.62) | |
A | 326 (56.0%) | 339(54.3%) | 0.346 | 0.556 | NS | 1.07(0.85–1.34) | |
G | 256(44.0%) | 285(45.7%) | 0.346 | 0.556 | NS | 0.93(0.74–1.17) |
OR = odds ratio; 95% CI = 95% confidence interval; pc = Bonferroni corrected P; NS = not significant.