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. 2013 Jun 28;8(6):e67464. doi: 10.1371/journal.pone.0067464

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© 2013 Ge et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fetal concentration in maternal plasma was calculated using both paternal and maternal homozygous but different type of loci. (a) Gene typing result of 478,685 loci were acquired for both parents. A total of 476,896+297 loci were homozygous for the father and 476,773+297 for the mother. There were 297 loci was homozygous in both parents but with different type and were used for fetal concentration calculation in maternal plasma. (b) Cff-DNA concentration and sequencing depth for each of the 297 loci.