Table 1. Game centrality of party hubs, date hubs and randomly selected nodes of a high-fidelity yeast protein-protein interaction network.
| Consensus party hubsb | Consensus date hubsb | Randomly selected nodesb | |
| Average Game Centrality (GC) of node setsa | 0.789±0.001c | 0.720±0.003 | 0.658±0.005 |
a
Prisoner’s dilemma game was simulated using the high-fidelity yeast interactome of Ekman et al. [36], and game centrality measures were calculated as described in Methods.
b
Initially all 2,444 nodes were cooperating except for 30 defecting nodes, which were randomly sampled 2000 times from 63 consensus party hubs (compiled as in [43], see Table S1 of Text S1), from 145 consensus date hubs (compiled as in [43], see Table S2 of Text S1), as well as from all the 2,444 nodes in the network.
c
Data represent sample means ± standard error. The distributions of the game centrality values were significantly different according to the chi-square test (χ2>400).