Table 2. Correlations of game centrality (GC) with degree, betweenness centrality and phenotypic potential of proteins in a high fidelity yeast interactome.
| Correlation valuesa | Degree | Betweenness Centrality | Game Centrality (GC) |
| Degree | – | 0.81±0.02b (p<0.001) | 0.61±0.04 (p<0.001) |
| Betweenness Centrality | – | – | 0.62±0.04 (p<0.001) |
| Phenotypic potential | 0.09±0.04 (p<0.022) | 0.07±0.04 (p<0.083) | 0.13±0.05c (p<0.007) |
Simulations of the prisoner’s dilemma game were performed as described in Methods using the parameter set of (R = 3, T = 6, S = 0, P = 1). Correlation values between degree, betweenness centrality, GC in prisoner’s dilemma game, as well as phenotypic potential [44] were calculated for the 2,444 proteins of the high fidelity yeast interactome of Ekman et al. [36].
Data represent Goodman-Kruskal’s gamma values ± standard errors. Significance levels in parentheses were also calculated using Goodman-Kruskal’s gamma test (the null hypothesis being that the correlation is different from zero).
Using the R-package correlation test (http://personality-project.org/r/html/r.test.html, [62]) the correlation between phenotypic potential and game centrality was significantly larger than the correlation between phenotypic potential and degree, or the correlation between phenotypic potential and betweenness centrality.