Table 2. Associations between maternal BMI and inhaled cortisone for children aged 6–16 years.
| 6–12 year olds | Proportion | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
| (n = 161,379) | receiving ICS | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) |
| Underweight | 4.5% (170/3,713) | 0.92 (0.78–1.07) | 0.92 (0.78–1.07) | 0.94 (0.80–1.10) | 0.94 (0.80–1.09) | 0.93 (0.80–1.09) | 0.93 (0.80–1.09) |
| Normal | 5.0% (4802/96,559) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Overweight | 5.7% (1692/29,847) | 1.15 (1.08–1.22) | 1.15 (1.09–1.22) | 1.16 (1.09–1.23) | 1.16 (1.09–1.23) | 1.15 (1.09–1.22) | 1.15 (1.09–1.22) |
| Obese Class-I | 6.5% (507/7,801) | 1.33 (1.21–1.46) | 1.33 (1.21–1.47) | 1.36 (1.23–1.49) | 1.36 (1.23–1.49) | 1.34 (1.22–1.48) | 1.34 (1.22–1.47) |
| Obese Class-II+ | 6.7% (173/2,598) | 1.36 (1.17–1.59) | 1.36 (1.16–1.59) | 1.38 (1.18–1.62) | 1.38 (1.18–1.62) | 1.36 (1.16–1.59) | 1.36 (1.16–1.59) |
| Missing | 5.2% (1,095/20,861) | 1.06 (0.99–1.13) | 1.06 (0.99–1.13) | 0.99 (0.92–1.07) | 0.99 (0.92–1.07) | 0.99 (0.92–1.06) | 0.99 (0.92–1.06) |
| 6–12 year olds | Proportion | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
| (n = 109,353) | receiving ICS | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) | OR (95%CI) |
| Underweight | 4.9% (163/3,303) | 0.94 (0.80–1.11) | 0.94 (0.80–1.11) | 0.95 (0.81–1.12) | 0.95 (0.81–1.12) | 0.95 (0.81–1.12) | 0.95 (0.81–1.12) |
| Normal | 5.2% (3,527/67,516) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| Overweight | 5.0% (801/15,950) | 0.96 (0.89–1.04) | 0.96 (0.88–1.03) | 0.97 (0.90–1.05) | 0.97 (0.90–1.05) | 0.97 (0.90–1.05) | 0.97 (0.90–1.05) |
| Obese Class-I | 5.8% (210/3,630) | 1.11 (0.97–1.29) | 1.11 (0.96–1.28) | 1.13 (0.98–1.31) | 1.13 (0.98–1.31) | 1.13 (0.98–1.31) | 1.13 (0.98–1.31) |
| Obese Class II+ | 5.8% (56/965) | 1.12 (0.85–1.47) | 1.11 (0.85–1.46) | 1.15 (0.87–1.51) | 1.15 (0.88–1.51) | 1.15 (0.88–1.52) | 1.15 (0.87–1.51) |
| Missing | 4.9% (884/17,989 | 0.94 (0.87–1.01) | 0.94 (0.87–1.01) | 0.94 (0.87–1.01) | 0.94 (0.87–1.01) | 0.93 (0.87–1.01) | 0.93 (0.86–1.01) |
Model 1. Simple adjustment: adjusted for year of birth and sex.
Model 2. Standard potential confounders: paternal asthma medication, socioeconomic indicators (maternal education, social welfare) maternal age, maternal smoking, county prescription pattern added.
Model 3. Maternal pre-pregnancy confounders related to obesity: pre-pregnancy risk factors: maternal history of diabetes and hypertension added.
Model 4. Pre birth potential mediators: pregnancy related complications: premature rupture of the membranes, preeclampsia, gestational diabetes, gestational hypertension, mode of delivery, gestational age (37–38 and 39–41), small and large for gestational age, maternal fever during labour, chorioamnionitis added.
Model 5. Pre birth potential mediators: post-birth complications of RDS, TTN, meconium aspiration added.