. 2013 Jun 28;8(6):e67361. doi: 10.1371/journal.pone.0067361

Table 3. Association of alterations in ALCAM, E-cadherin and β-catenin expression with evolution of OSCC, clinical parameters and disease prognosis: Multivariate Analysis.

Logistic regression analysis: Transition	p_value	OR	95% C.I.
Normal to Oral Lesions
ALCAM C⁺	0.024	11.6	1.4–98.2
Hyperplasia to Dysplasia
β-cat M^-	0.01	4.2	1.3–12.6
Oral Lesions to Cancer
E-cad M^-	0.02	2.0	1.1–3.7
Clinical parameters	p_value	OR	95% C.I.
Tumor Stage
β-cat M^-	0.001	4.2	1.8–10.2
β-cat NC	0.027	3.1	1.1–8.3
Nodal Involvement
β-cat M^-	0.003	3.8	1.6–9.3
ALCAM⁺/β-cat NC	0.025	3.4	1.2–9.7
Stage
β-cat M^-	0.000	8.7	3.3–22.9
ALCAM⁺/β-cat NC	0.006	9.9	1.9–51.5
Cox-proportional hazard model for disease free survival analysis	p_value	HR	95% C.I.
ALCAM C⁺/E-cad M^-	0.000	4.8	2.2–9.9

OR, Odd’s ratio; HR, Hazard’s ratio.