Table 3. Association of alterations in ALCAM, E-cadherin and β-catenin expression with evolution of OSCC, clinical parameters and disease prognosis: Multivariate Analysis.
Logistic regression analysis: Transition | pvalue | OR | 95% C.I. |
Normal to Oral Lesions | |||
ALCAM C+ | 0.024 | 11.6 | 1.4–98.2 |
Hyperplasia to Dysplasia | |||
β-cat M- | 0.01 | 4.2 | 1.3–12.6 |
Oral Lesions to Cancer | |||
E-cad M- | 0.02 | 2.0 | 1.1–3.7 |
Clinical parameters | pvalue | OR | 95% C.I. |
Tumor Stage | |||
β-cat M- | 0.001 | 4.2 | 1.8–10.2 |
β-cat NC | 0.027 | 3.1 | 1.1–8.3 |
Nodal Involvement | |||
β-cat M- | 0.003 | 3.8 | 1.6–9.3 |
ALCAM+/β-cat NC | 0.025 | 3.4 | 1.2–9.7 |
Stage | |||
β-cat M- | 0.000 | 8.7 | 3.3–22.9 |
ALCAM+/β-cat NC | 0.006 | 9.9 | 1.9–51.5 |
Cox-proportional hazard model for disease free survival analysis | pvalue | HR | 95% C.I. |
ALCAM C+/E-cad M- | 0.000 | 4.8 | 2.2–9.9 |
OR, Odd’s ratio; HR, Hazard’s ratio.