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Disruption of the SorCS1c YAQM does not affect SorCS1–APP–Vps35 complex formation. A, B, H4 wt APP cells were transfected with pCDNA4 (control transfection), SORCS1c-myc, or SORCS1cY1132A, as indicated. Lysates were prepared as described, and a 300 μg aliquot of protein lysate was used for immunoprecipitation using A/G plus agarose beads (Santa Cruz Biotechnology) with 2 μg of anti-myc antibody according to the manufacturers instructions. B, Control IgG immunoprecipitation.
