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. 2013 Apr 17;33(16):7099–7107. doi: 10.1523/JNEUROSCI.5270-12.2013

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Copyright © 2013 the authors 0270-6474/13/337099-09$15.00/0

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Figure 5. — Disruption of the SorCS1c YAQM motif decreases APP localization to the TGN. A–C, Indirect immunofluorescence of TGN38 (A, first panel), APP (A, second panel), and merged (A, third panel); EEA1 (B, first panel), APP (B, second panel), and merged (B, third panel); Rab7 (C, first panel), APP (C, second panel), and merged (C, third panel) in permeabilized fixed H4 wt APP cells expressing pCDNA4 (C, first panel), wt SORCS1C (C, second panel), SORCS1C^Y1132A (C, third panel), or SORCS1C^M1135A (fourth panel). Cells are representative of a field of three independent experiments. Scale bar, 25 μm. See Table 2 for quantification.