Table 1.

Tyrosine-based internalization motif YAQM within the SorCS1c cytoplasmic domain regulates internalization of SorCS1c but not APP

pCDNA APP	SORCS1		SORCS1Y1132A		SORCS1M1135A
	APP	SorCS1	APP	SorCS1	APP	SorCS1
2.43 ± 0.27	2.07 ± 0.48	0.62 ± 0.1	1.73 ± 0.19	1.33 ± 0.14	1.58 ± 0.05	0.86 ± 0.06

Cell surface fluorescence for APP and SorCS1-myc shown in Figure 1D was quantified using ImageJ software and is expressed as the CTCF ± SEM.