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. 2013 Jun 12;169(5):953–962. doi: 10.1111/bph.12193

Figure 4.

Figure 4

LASSBio-1359 attenuates pulmonary vascular remodelling in MCT-induced PAH. (A) Representative images of H&E-stained lung sections of rats exposed to saline (control), MCT, MCT + vehicle (DMSO), or MCT + LASSBio-1359 (50 mg·kg−1, p.o.). Images show vessels at 40 × magnification. (B) Wall thickness expressed as a percentage of the total area of the vessel (<50 μm). (C) Wall thickness of vessels ranging between 50 and 150 μm in external diameter. Each column represents the mean ± SEM (n = 6). *P < 0.05, **P < 0.01 versus. control; ††P < 0.01 versus MCT; ‡‡P < 0.01 versus MCT + vehicle.