Table 2.
Plasma levels of alanine aminotransferase (ALAT), aspartyl aminotransferase (ASAT), total cholesterol and HDL-cholesterol in the 4-week chronic studies in db/db mice
| ALAT (U·L−1) | ASAT (U·L−1) | Total cholesterol (g·L−1) | HDL-cholesterol (g·L−1) | |
|---|---|---|---|---|
| Vehicle | 151.3 ± 30.7 | 197.5 ± 34.1 | 1.252 ± 0.066 | 0.801 ± 0.039 |
| N00236460 | 121.0 ± 20.3 | 295.8 ± 78.0 | 1.180 ± 0.030 | 0.708 ± 0.015 |
| S 50131a | 126.8 ± 14.1 | 216.0 ± 43.7 | 1.274 ± 0.046 | 0.740 ± 0.025 |
| S 50131b | 125.9 ± 13.7 | 314.2 ± 48.1 | 1.376 ± 0.049 | 0.812 ± 0.023 |
| Vehicle | 106.1 ± 14.0 | 260.5 ± 75.2 | 1.385 ± 0.058 | 0.824 ± 0.029 |
| GKA50 | 129.2 ± 32.0 | 275.1 ± 77.2 | 1.292 ± 0.055* | 0.737 ± 0.028 |
| S 51434a | 92.8 ± 9.0 | 174.4 ± 43.6 | 1.376 ± 0.041 | 0.827 ± 0.017 |
| S 51434b | 176.4 ± 60.2 | 443.4 ± 117.2 | 1.313 ± 0.049 | 0.836 ± 0.027 |
Results are means ± SEM of at least nine mice per group.
*
P < 0.05 significantly different from vehicle.
a
Low-dose group.
b
High-dose group.