Table 1.
pEC50 and Emax values of UCB1244283 for sites labelled with [3H]UCB30889 on rat cortex and human and rat recombinant SV2A expressed in HEK cells at different temperatures
| T (°C) | Rat cortex | Human recombinant SV2A | Rat recombinant SV2A | |
|---|---|---|---|---|
| pEC50 | 4 | 4.75 ± 0.45 | 5.72 ± 0.03 | 6.05 ± 0.19 |
| 25 | 5.52 ± 0.11 | 5.64 ± 0.08 | ||
| 37 | 5.47 ± 0.16 | 5.43 ± 0.19 | ||
| Emax (% of B0) | 4 | 571 ± 181 | 706 ± 47 | 522 ± 34 |
| 25 | 735 ± 70 | 824 ± 141 | ||
| 37 | 880 ± 118 | 835 ± 45 |
Data are presented as mean ± SD (n = 3) and were obtained by analysis of competition curves as presented in Figure 2, using a non-linear regression model with variable slope as described in materials and methods. Hill slopes were not significantly different from unity.