Figure 7.

The effect of oestrone derivatives on BK_Ca currents evoked in HEK 293 cells over expressing α and β₁ subunits of the BK_Ca channel. The normalized peak currents over time curves were compared to control and found not to be significantly different, apart from oestrone, Oestrone oxime and Quat DME-oestradiol, which demonstrated a significant enhancement in peak current. The currents were evoked by stepping the membrane potential from −40 mV to +60 mV. (*P < 0.5 compared with control data, Kruskal–Wallis test followed by a Dunns multiple comparison test).