Table 1.

Effect of chronic estrogen and intrapituitary tumor IGF-I gene therapy on serum PRL levels

Time point	Intact	E2 only	E2 + RAd-GFP	E2 + RAd-IGF-I
–25 days	90 ± 14	73 ± 16	76 ± 24	82 ± 7
–15 days	76 ± 14	80 ± 13	151 ± 24	78 ± 15
–10 days	88 ± 20	180 ± 45*	197 ± 22	190 ± 24
0 day	59 ± 18	347 ± 50*	189 ± 58	241 ± 40
+7 days	65 ± 12	308 ± 60*	260 ± 57	138 ± 22*

Serum PRL (ng/ml) was measured in blood samples taken serially from experimental day −25 to experimental day +7. The number of rats used was 5 for all groups. E₂ = Estrogen. * p < 0.01 (intact vs. E₂ only and E₂ + RAd-GFP vs. E₂ + RAd-IGF-I).