Baseline serology titers by respiratory culture status using modified Leeds criteria. Subjects were classified as ‘Pa free’ if they were clear of P. aeruginosa from baseline through end of study, ‘Intermittent’ if they had less than half of all available cultures testing positive for P. aeruginosa, and ‘Chronic’ if they had half or more of all available cultures testing positive for P. aeruginosa. Hash lines are the median values, boxes represent the 25th and 75th percentiles (inter-quartile range), whiskers extend to minimum and maximum or 1.5× the inter-quartile range (whichever is smaller), outliers are marked as circles.