Skip to main content
. Author manuscript; available in PMC: 2014 Apr 26.
Published in final edited form as: J Nat Prod. 2013 Mar 21;76(4):685–693. doi: 10.1021/np300913h

Figure 1.

Figure 1

Genomics-guided discovery of thailanstatins (1–3). (A) A graphical comparison of the FR901464 (4) biosynthetic gene cluster (fr9) and the thailanstatin biosynthetic gene cluster (tst). (B) Identification with RT-PCR analysis of three growth media in which the regulatory tstA gene is expressed. (C) HPLC profiling of a crude extract of B. thailandensis MSMB43 fermentation broth and identification of three compound peaks with a conjugated diene-like characteristic UV absorbance (UVmax at 235 nm).