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. Author manuscript; available in PMC: 2014 Apr 26.
Published in final edited form as: J Nat Prod. 2013 Mar 21;76(4):685–693. doi: 10.1021/np300913h

Figure 2.

Figure 2

Proposed biosynthetic pathway of thailanstatin A (1) in B. thailandensis MSMB43. Crossed domains are inactive or nonfunctional, star-labeled domains are atypical. See text for explanations. A, adenylation; ACP, acyl carrier protein; AT, acyltransferase; C, condensation; DH, dehydratase; ECH, enoyl-CoA hydratase; ER, enoyl reductase; GAT, glyceryl transferase/phosphatase; KR, ketoreductase; KS, ketosynthetase; MT, methyltransferase; OX, FAD-dependent monooxygenase; PCP, peptidyl carrier protein; TE, thioesterase.