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In vitro pre-mRNA splicing inhibitory activities. The final half-maximal inhibitory concentration (IC50 in µM) is the average of two independently performed triplicate assay results (in nM) with standard deviation provided.
| Compound | IC50-1 (nM) | IC50-2 (nM) | Final IC50 (µM) |
|---|---|---|---|
| Thailanstatin A (1) | 399.03 | 902.01 | 0.65±0.36 |
| Thailanstatin B (2) | 4432.58 | 7928.34 | 6.18±2.47 |
| Thailanstatin C (3) | 4786.66 | 8883.36 | 6.84±2.90 |
| FR901464 (4) | 535.56 | 633.09 | 0.58±0.07 |
