Table 3.
Antiproliferative activities in human cancer cell lines. The half-maximal growth inhibition concentration (GI50 in nM) is the average of triplicate well results with standard deviation provided.
GI50 (nM) | ||||
---|---|---|---|---|
Compound | DU-145 | NCI-H232A | MDA-MB-231 | SKOV-3 |
Thailanstatin A (1) | 1.11±0.02 | 2.26±0.17 | 2.58±0.11 | 2.69±0.37 |
Thailanstatin B (2) | 3.00±0.92 | 2.50±0.06 | 6.22±1.67 | 4.94±1.76 |
Thailanstatin C (3) | 2.98±0.90 | 3.67±0.53 | 8.82±2.20 | 5.57±2.01 |
FR901464 (4) | 1.05±0.02 | 1.94±0.24 | 2.10±0.19 | 1.06±0.01 |