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. Author manuscript; available in PMC: 2014 Apr 26.
Published in final edited form as: J Nat Prod. 2013 Mar 21;76(4):685–693. doi: 10.1021/np300913h

Table 3.

Antiproliferative activities in human cancer cell lines. The half-maximal growth inhibition concentration (GI50 in nM) is the average of triplicate well results with standard deviation provided.

GI50 (nM)

Compound DU-145 NCI-H232A MDA-MB-231 SKOV-3
Thailanstatin A (1) 1.11±0.02 2.26±0.17 2.58±0.11 2.69±0.37
Thailanstatin B (2) 3.00±0.92 2.50±0.06 6.22±1.67 4.94±1.76
Thailanstatin C (3) 2.98±0.90 3.67±0.53 8.82±2.20 5.57±2.01
FR901464 (4) 1.05±0.02 1.94±0.24 2.10±0.19 1.06±0.01