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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neuropharmacology. 2013 May 2;0:96–105. doi: 10.1016/j.neuropharm.2013.04.040

Figure 2.

Figure 2

Effects of ketoprofen pretreatment during stress on stress and Meth-induced hyperthermia. Meth (7.5 mg/kg q 2hrs, ×4 ip) or saline (1 mL/kg q 2hrs, ×4 ip) was administered to previously stressed or control rats. Some rats received ketoprofen (5 mg/kg, sc) 1 hr before each stressor or handling. Body temperatures were measured before and every hr after each Meth or saline injection (indicated by the arrows on the x-axis). Meth significantly increased body temperature over time (*, p<0.001) and prior exposure to 10 days of CUS significantly enhanced Meth-induced hyperthermia (#, p<0.001), as revealed by a two-way repeated measures ANOVA. Ketoprofen had no significant effect on stress or Meth-induced hyperthermia. (n=6–9 for each group)