Table 2.
Clinical outcomes in first 100 days after second HCT
| Variable N (%) | Allo-allo (n = 55) | Auto-allo (n = 190) |
|---|---|---|
|
| ||
| Cumulative incidence of relapse | 14 (25) | 40 (21) |
|
| ||
| Cumulative incidence of grades II-IV acute GVHD | 34 (62) | 128 (67) |
|
| ||
| Regimen related toxicity (≥ grade 3)/ Infections | ||
| Pulmonary | 10 (18) | 29 (15) |
| Veno-occlusive disease/sinusoidal obstructive syndrome | 8 (15) | 10 (5) |
| Renal/bladder | 9 (16) | 79 (42) |
| Infections | 29 (53) | 117 (62) |
|
| ||
| Number of deaths | 13 (24) | 24 (13) |
|
| ||
| Cause of death1 | ||
| Relapse | 3 (23) | 3 (33) |
| Graft-vs.-Host disease | 1 (7) | 5 (20) |
| Infection | 5 (38) | 6 (25) |
| Other | 5 (38) | 9 (38) |
Abbreviations: HCT, Hematopoietic cell transplantation; Allo-allo, 2 allogeneic transplants; Auto-allo, autologous transplant followed by allogeneic transplant
1
Sum of percentages > 100% since multiple causes of death were listed for some patients