Table 4.
Measures of tremor and ataxia stratified by age group
| Measure and carrier status (no. of repeats) | Age group (years)
|
OR (95 CI)* | p Value | ||
|---|---|---|---|---|---|
| 51–59 | 60–69 | ≥70 | |||
| Sway (eyes open) | N/A | ||||
| <70 | |||||
| n | 7 | 7 | 5 | ||
| % | 0 | 0 | 0 | ||
| Mean (SD) | 8.5 (3.5) | 13.0 (0.8) | 15.8 (3.5) | ||
| 70–199 | |||||
| n | 10 | 20 | 14 | ||
| % | 0 | 25.0 | 42.9 | ||
| Mean (SD) | 14.8 (4.2)† | 18.0 (9.3)† | 23.2 (14.3) | ||
| Sway (eyes closed) | 4.88 (1.79 to 13.31) | 0.002 | |||
| <70 | |||||
| n | 7 | 7 | 5 | ||
| % | 0 | 0 | 60.0 | ||
| Mean (SD) | 12.6 (5.4) | 24.4 (5.0) | 40.2 (13.1) | ||
| 70–199 | |||||
| n | 10 | 20 | 14 | ||
| % | 40.0 | 50‡ | 50.0 | ||
| Mean (SD) | 35.7 (16.6)† | 40.5 (24.9)† | 37.5 (20.3) | ||
| Postural tremor I | 2.06 (0.73 to 5.80) | 0.17 | |||
| <70 | |||||
| n | 9 | 7 | 8 | ||
| % | 10.0 | 14.3 | 50.0 | ||
| Mean (SD) | 0.1 (0.1) | 0.1 (0.1) | 0.2 (0.1) | ||
| 70–199 | |||||
| n | 14 | 26 | 15 | ||
| % | 35.7 | 34.6 | 46.7 | ||
| Mean (SD) | 0.2 (0.1) | 0.2 (0.2) | 0.2 (0.3) | ||
| Postural tremor II | 0.84 (0.19 to 3.65) | 0.82 | |||
| <70 | |||||
| n | 10 | 8 | 8 | ||
| % | 10.0 | 12.5 | 25.0 | ||
| Mean (SD) | 0.3 (0.1) | 0.3 (0.3) | 0.5 (0.2) | ||
| 70–199 | |||||
| n | 14 | 26 | 15 | ||
| % | 0 | 19.2 | 20.0 | ||
| Mean (SD) | 0.3 (0.1) | 0.4 (0.2) | 0.4 (0.2) | ||
| Intention tremor | 3.28 (0.84 to 12.76) | 0.09 | |||
| <70 | |||||
| n | 10 | 6 | 8 | ||
| % | 0 | 0 | 12.5 | ||
| Mean (SD) | 0.2 (0.1) | 0.3 (0.1) | 0.4 (0.4) | ||
| 70–199 | |||||
| n | 14 | 27 | 15 | ||
| % | 7.1 | 25.9 | 6.7 | ||
| Mean (SD) | 0.3 (0.4) | 0.7 (1.0) | 0.4 (0.2) | ||
Data are sample size (n), percentage of patients who scored >2SD above the mean, and overall mean and SD of intensity measure.
*
Adjusted for age at testing.
†
The t test (comparing two repeat-size groups within an age group), significant at p<0.05.
‡
Fisher exact test (comparing two repeat-size groups within an age group) significant at p<0.05.