TABLE IV.
Results From Logistic Regression Models Analyzing Interactions Between Having a Child With FXS and CRHR1 SNP Genotypes to Predict the Presence of Probable Social Phobia, as Measured by an SPAI Social Phobia Score of ≥80
| CRHR1 SNP | Genotype | No FXS child
|
Has FXS child
|
Interaction P-value | ||
|---|---|---|---|---|---|---|
| N | % With SP | N | % With SP | |||
| rs7209436 | CC | 110 | 21.8 | 66 | 15.2 | 0.0002 |
| CT | 140 | 11.4 | 82 | 24.4 | ||
| TT | 37 | 2.7 | 20 | 30.0 | ||
| rs110402 | GG | 97 | 19.6 | 59 | 18.6 | 0.0390 |
| AG | 150 | 12.7 | 83 | 22.9 | ||
| AA | 41 | 9.8 | 26 | 23.1 | ||
| rs242924 | GG | 101 | 18.8 | 61 | 16.4 | 0.0238 |
| GT | 145 | 12.4 | 81 | 23.5 | ||
| TT | 41 | 9.8 | 25 | 24.0 | ||
| rs242940 | AA | 96 | 19.8 | 58 | 17.2 | 0.0382 |
| AG | 136 | 12.5 | 81 | 24.7 | ||
| GG | 53 | 7.5 | 28 | 17.9 | ||
| rs173365 | AA | 80 | 26.3 | 37 | 18.9 | 0.0052 |
| AG | 135 | 11.1 | 86 | 20.9 | ||
| GG | 73 | 6.8 | 44 | 22.7 | ||
| TAT genotype | 0 Copies | 110 | 20.9 | 68 | 17.6 | 0.0016 |
| 1 Copy | 140 | 11.4 | 78 | 23.1 | ||
| 2 Copies | 34 | 2.9 | 19 | 26.3 | ||
FXS, fragile X syndrome.