Table 3.
Pharmacokinetic parameters of γ-tocotrienol in plasma after single intravenous administration at 2 mg/kg to rats (n = 5).
| Cmax* (ng/mL) | 17515 ± 6526 |
| A* (ng/mL) | 15782 ± 6186 |
| T1/2α* (min) | 10.4 ± 9.9 |
| B* (ng/mL) | 1732 ± 350 |
| T1/2β* (min) | 183.6 ± 28.9 |
| AUC0-∞* (min·ng/mL) | 617317 ± 6719 |
| Cl* (mL/kg/min) | 3.24 ± 0.04 |
| V1* (mL/kg) | 138.8 ± 85.2 |
| V2* (mL/kg) | 492.5 ± 29.7 |
| Vss* (mL/kg) | 631.3 ± 59.5 |
*
Cmax = maximum concentration; A = coefficients of distributional phase; T1/2α = elimination half-life of distributional phase; B = coefficients of terminal phase; T1/2β = elimination half-life of terminal phase; AUC0-∞ = area under curve from time zero to infinity; Cl = total body clearance; V1 = volume of distribution of central compartment; V2 = volume of distribution of peripheral compartment; Vss = volume of distribution at steady state.