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. Author manuscript; available in PMC: 2013 Jun 30.
Published in final edited form as: Expert Rev Mol Diagn. 2013 Apr;13(3):257–269. doi: 10.1586/erm.13.15

Figure 1. The design of PEGylated tumor-homing polymeric nanoparticle system, P-HA-NP.

Figure 1

(A) Chemical structure of P-HA-NP. Inset: transmission electron microscopy image of P-HA-NP. (B) Selective tumor cell update and drug release of P-HA-NPs (green, P-HA-NP; red, drug; blue, nucleus). (C) Near-infrared optical imaging of tumor accumulation (arrow) of Cy5.5-labeled P-HA-NPs in a HT29 colon tumor-bearing mouse. (D) Therapeutic efficacy of irinotecan encapsulated polymeric nanoparticles, IRT-P-HA-NPs. *p < 0.05.

HA: Hyaluronic acid; IRT: Irinotecan; NP: Nanoparticles.

Reproduced with permission from [19].