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. 2013 Jun 10;123(7):2791–2802. doi: 10.1172/JCI66827

Figure 6. Interaction of FcγRIIb with Aβ1-42 is linked to i.c.v.

Figure 6

Aβ1-42-induced memory impairment. (A–C) Suppression of i.c.v. Aβ1-42-induced cognitive defects in Fcgr2b-deficient mice. Mice were i.c.v. injected with nontoxic Aβ40-1 or Aβ1-42 (410 pm). One day later, Y-maze (A; **P < 0.005, 1-way ANOVA), passive avoidance (B; n = 10 for each group; *P < 0.05, 1-way ANOVA), and novel object recognition (C; n = 10 for each group) tests were performed as described in the methods. Bars represent the mean ± SEM. (D and E) Suppression of i.c.v. Aβ1-42-induced memory impairment by the peptides inhibiting the interaction between Aβ1-42 and FcγRIIb. WT mice (2-month-old) were i.c.v. injected with Aβ40-1 or Aβ1-42 (410 pm) alone or together with Aβ1-9 (#1), Aβ1-9 mutant (#7), or FcγRIIb107-114 (#9) peptide (molar ratio of 1:3). One day later, the mice were analyzed using Y-maze (D) and passive avoidance (E) tests (n = 8–10). Bars represent the mean ± SEM. **P < 0.005; ***P < 0.001; 1-way ANOVA.