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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Nat Genet. 2012 Jul 22;44(8):955–959. doi: 10.1038/ng.2354

Figure 1.

Figure 1

Imputation schematic. Each box represents a genetic dataset and each arrow represents an analysis step. The sizes of the boxes reflect the relative numbers of genotypes they contain, and the widths of the arrows reflect the relative computational costs of the analyses. Given a single GWAS dataset (red box), successively larger reference panels (blue boxes) lead to larger and more accurate imputed datasets (orange boxes). The computational cost of imputation is much lower when using pre-phased GWAS haplotypes (green box, right-hand side) than when using traditional imputation approaches (left-hand side).