Figure 1.

Increased numbers and disturbed differentiation of CD8⁺ T cells. (A) Absolute numbers of total and CD4⁺ and CD8⁺ T cells, CD4/CD8 ratio, CD3⁻CD56⁺ NK cells and CD19⁺ B cells. Dotted lines indicate upper and lower limits of normal for corresponding age (changing at age 10 years), for CD4/CD8 ratio only the lower limit of normal is shown. (B) Distribution of naïve, memory and effector-memory T cells in both CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells (i.e. CD45RA⁺CD27⁺, CD45RA⁻CD27⁺, CD45RA^+or−CD27⁻, respectively), at 11 years of age compared to values in a 10-year old healthy control. Lower panels: B-cell differentiation (naïve, non-switched or class-switched memory, i.e. sIgD⁺CD27⁻sIgD⁺CD27⁺ or sIgD⁻CD27⁺).