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. 2013 Jul;98(7):1115–1123. doi: 10.3324/haematol.2012.073080

Figure 2.

Figure 2.

Tie2-expressing monocytes (TEM) in CLL patients and normal controls. (A) Flow cytometric analysis shows the percentage of Tie2+ cells among CD14+ monocytes, gated on the DUMP− channel. (B) Histograms represent mean ± SEM of TEM count/μL in CLL patients (n=26) and healthy age-matched controls (n=13) and also within CLL patients divided according to FISH abnormalities. CLL patients had higher numbers of TEM compared to normal controls. Moreover, CLL patients harboring high-risk FISH abnormalities, in particular deletion 17p, had higher numbers of TEM in peripheral blood. (*P<0.05, Mann-Whitney test). (C) TEM count/μL correlates positively with Angiopoietin-2 (Ang2) plasma levels (Rho=0.42, P=0.032, Spearman’s non-parametric test).