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. 2013 May 17;288(26):18624–18642. doi: 10.1074/jbc.M112.442954

FIGURE 2.

FIGURE 2.

Liver injury develops in HFD fed CHOP knock-out (Chop−/−) mice (n = 5–6 per group). A, relative liver weight of all four experimental groups is shown. Chop−/− mice developed significant hepatomegaly upon HFD-feeding for 16 weeks (*, p < 0.05). B, histologic steatosis score for all four groups is shown. HFD-fed Chop−/− mice had the greatest hepatic steatosis, significantly greater than the Chop+/+ group (*, < 0.001). C, alanine transaminase levels from all four groups are shown. HFD-fed Chop−/− mice had the greatest elevations in serum alanine transaminase (*, p < 0.05, compared with HFD-fed Chop+/+). D, histologic inflammation score for the four groups is shown. Significantly greater inflammation was observed in the HFD-fed Chop−/− mice (p < 0.05, compared with HFD-fed Chop+/+). E, representative H&E-stained liver sections from all four groups are shown. The bottom right panel from HFD-fed Chop−/− mice demonstrates characteristic features of steatohepatitis. The arrows point to inflammatory foci surrounding steatotic hepatocytes.