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. 2013 May 17;288(26):18624–18642. doi: 10.1074/jbc.M112.442954

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Cell death in Chop^+/+ and Chop^−/− macrophages. A, BMDMs from Chop^+/+ (WT) and Chop^−/− (KO) were treated with PA. Apoptosis in both was concentration- and time-dependent but was significantly abrogated in BMDM from Chop^−/− mice (*, p < 0.05). VA, vehicle. B, representative fluorescent photomicrographs of BMDM nuclei stained with DAPI from PA-treated Chop^+/+ and Chop^−/− are shown. The white arrows point to apoptotic nuclei. Cells were treated with 400 μm palmitic acid for the indicated times. C, immunofluorescence for F4/80 is shown in red, and a TUNEL assay is in green for CD-fed and high fat diet-fed Chop^+/+ and Chop^−/− mice. The arrow points to an apoptotic F4/80 positive macrophage in HFD-fed Chop^+/+ liver.