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. 2013 May 13;288(26):18853–18862. doi: 10.1074/jbc.M112.443671

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Effect of neurosphere conditioned medium on NSPC proliferation. A, effect of unconditioned medium, conditioned medium from Tg2576 neurosphere cultures (CM-Tg2576), and conditioned medium from C57Bl/6xSJL neurosphere cultures (CM-C57Bl/6xSJL) on the growth of C57Bl/6xSJL NSPCs. Medium was conditioned for 7 days prior to adding to cultures to test for the effect on proliferation over a period of 5 days. Cell number is shown as a the percentage of the fluorescence intensity measured in an alamarBlue assay when compared with control (unconditioned medium). Values are means + S.E. * = significantly different from unconditioned medium (control) (p < 0.05). ** = significantly different from unconditioned (control) medium and from CM-C57Bl/6xSJL (p < 0.05). B, effect of unconditioned medium, conditioned medium from APP knock-out neurosphere cultures (CM-APP-KO), and conditioned medium from C57Bl/6 neurosphere cultures (CM-C57Bl/6) on the growth of wild-type (C57Bl/6) NSPCs. Cell number is represented by the percentage of the fluorescence intensity measured in an alamarBlue assay when compared with control (unconditioned medium). Values are means + S.E. * = significantly different from unconditioned (control) medium (p < 0.05). *** = significantly different from unconditioned (control) medium and from CM-C57Bl/6 (p < 0.05).