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. 2013 Apr 30;288(26):18923–18938. doi: 10.1074/jbc.M113.467316

FIGURE 1.

FIGURE 1.

Structure of the RbAB domain and its LXCXE and E2F ligands. A ribbon representation of the RbAB domain (Protein Data Bank code 1N4M) indicating the relative orientations of the RbAB A and B subdomains (dark and light gray, respectively) is shown. The HPV E7(21–29) peptide containing the LXCXE motif (Protein Data Bank code 1GUX; red) binds to a conserved surface cleft located in the B subdomain, whereas the E2F-TD(407–426) peptide (Protein Data Bank code 1N4M; green) binds to a conserved groove formed by the A/B interface. The three tryptophan residues in RbAB are depicted (cyan spheres) and are located in the hydrophobic core of the A subdomain (Trp-516), in the A/B interface (Trp-563), and in the B subdomain (Trp-681). The fraction of accessible surface area for these residues is 0.41 (Trp-516), 0.00 (Trp-563), and 0.01 (Trp-681).