FIGURE 4.

POM-1 enhances the effects of ATP on pro-fibrotic marker expression of CFs. A, incubation of CFs with POM-1 together with ATP for 4 h increased expression of α-SMA, PAI-1, and TGF-β mRNA by 1.9-, 3.0-, and 1.7-fold, respectively, compared with CFs incubated only with ATP. B, incubation of CFs with POM-1 for 24 h increased α-SMA and PAI-1 protein expression by 30 and 89%, respectively, as compared with CFs incubated only with ATP. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus untreated controls (cont); +, p < 0.05; ++, p < 0.01 between groups indicated. Data are presented as mean ± S.E. of at least three independent experiments. veh, vehicle.