FIGURE 5.

POM-1 enhances the stimulatory effect of ATP on collagen synthesis and gel contraction. A, incubation of CFs with 30 μm POM-1 increased the effect of 10 μm ATP on collagen synthesis 73% after 24 h as compared with CFs incubated only with ATP. B, POM-1 increased the 12% reduction in collagen gel surface area in response to a 24-h incubation with 10 μm ATP to 32%. *, p < 0.05; **, p < 0.01, ***, p < 0.001 versus untreated controls (cont); +++, p < 0.001 between groups indicated. Quantitative data are presented as mean ± S.E. of three independent experiments.